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CAR can regulate CYP3A genes through SXR response elements and SXR can regulate CYP2B genes via adaptive recognition of the phenobarbital response element (PBRE), as revealed by receptor-DNA binding analysis and transfection assays [Xie et al. The cross-regulation of these two receptors was further evaluated in vivo, anavar achat en ligne anabola steroider typer. Constitutively active SXR (VP-SXR) transgenic mice showed sustained induction of CYP3A and CYP2B [Xie et al. However, constitutively active CAR (VP-CAR) transgenic mice showed only CYP2B induction; CYP3A was unchanged [Saini et al. It was subsequently shown that CAR only exhibits very weak binding and functional activation of the CYP3A4 promoter, instead showing a pronounced selectivity for CYP2B6 over CYP3A4 [Faucette et al. However the former crystallized as an octamer while the latter crystallized as a tetramer, anavar achat en ligne anabola steroider typer. 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